e-book Advances in Combination Therapy for Asthma and COPD

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Sacs inside them called alveoli grow too large. Their tissue breaks down, and that causes severe shortness of breath. You may hear about stem cell therapy clinics that claim to treat or cure COPD, but steer clear of them for now. Is there hope for stem cell therapy for COPD? The methodology of our study differs from those of previous studies usually assessing asthma exacerbation during ongoing therapy.


Recently, Peters et al. However, it seems that changes in the ACT score better measure real-life day-to-day asthma control, especially in patients with mild to moderate asthma, in whom the risk of exacerbation is relatively low. Therefore, the ACT score is a much better primary end point in such a group of patients with asthma such as ours. Patient adherence is bidirectionally affected by satisfaction with use of the drug and its tolerance.

This statement is supported by the very low number of patients who discontinued its use. Our data are in line with previous findings. It should be stressed that the physicians participating in this study reported a single adverse event a cough after application. A potential reason for such a low number of adverse events in our study in relation to controlled randomized trials was the lack of on-site monitoring.

According to the clinical judgment of the investigators, the proportion was very low—0. However, ineffectiveness might be the cause of therapy modification by another physician in an additional nine patients.

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In this case we can conclude that the ineffectiveness was not greater than 0. The main limitation of the current study was the lack of on-site monitoring by a contract research organization and the lack of on-site verification of original medical documentation regarding efficacy data and adverse events by qualified staff. Furthermore, the adherence was probably overestimated as it was assessed on the basis of self-reported data, with use of the MAQ.

Europharma M. Rachtan Co. All authors had full access to all of the data in this study and take complete responsibility for the integrity of the data and accuracy of the data analysis. All named authors meet the International Committee of Medical Journal Editors criteria for authorship for this article, take responsibility for the integrity of the work as a whole, and have given final approval for the version to be published. Ltd Director of the Department of Pharmacovigilance.

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  8. Jerzy Chudek received honorarium for data analysis and manuscript drafting. According to Polish law Journal of Laws , No Skip to main content Skip to sections. Advertisement Hide. Download PDF. Open Access. First Online: 08 November Methods This multicenter PAES was conducted by unselected allergologists and pulmonologists who enrolled adult outpatients age Results The percentage of patients with well-controlled asthma or total control of asthma ACT score points increased from Funding Orion Corporation.

    In addition, overall self-assessment of the inhaler and the complexity of the instructions for use of the inhaler on a six-point scale was done by the patient during the three visits. According to the Global Initiative for Asthma classification [ 8 ], most patients had mild chronic asthma The drop-out of patients from the study groups could impact this observation. At the first visit, The percentage of patients with well-controlled or total control of asthma increased to Open image in new window.

    The mean ACT score increased by 4. Patient satisfaction with the use of the inhaler increased with the duration of use.

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    ANOVA analysis of variance. Chrystyn H. Clin Drug Investig. Thorsson L, Edsbacker S.